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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.

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Related Experiment Video

Updated: Jun 10, 2026

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm
09:23

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Published on: January 28, 2011

DNA methylation systems and targets in plants.

Peter Meyer1

  • 1University of Leeds, Centre for Plant Sciences, Leeds, UK. p.meyer@leeds.ac.uk

FEBS Letters
|August 24, 2010
PubMed
Summary

Plants utilize DNA methyltransferases for cytosine methylation, guided by RNA transcripts and epigenetic pathways. While patterns are maintained, their variability

Area of Science:

  • Plant molecular biology
  • Epigenetics
  • Genomics

Background:

  • DNA methylation is crucial for regulating gene expression in plants.
  • Three types of DNA methyltransferases establish and maintain cytosine methylation patterns.
  • RNA transcripts recruit DNA methylation machinery to specific genomic loci.

Purpose of the Study:

  • To explore the mechanisms of DNA methylation establishment and maintenance in plants.
  • To understand the interplay between DNA methylation, RNA transcripts, and epigenetic pathways.
  • To highlight the gap in knowledge regarding DNA methylation variability and its functional significance.

Main Methods:

  • The study synthesizes current knowledge on DNA methyltransferases and epigenetic regulation.
  • It reviews the roles of RNA transcripts in directing methylation.

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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm
09:23

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Published on: January 28, 2011

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

  • It discusses the maintenance mechanisms involving DNA methylation and histone mark feedback loops.
  • Main Results:

    • DNA methyltransferases establish and maintain methylation at heterochromatic and euchromatic regions.
    • Epigenetic pathways, involving RNA recruitment and histone mark feedback, control methylation patterns.
    • Maintenance systems ensure faithful propagation of DNA methylation patterns.

    Conclusions:

    • Detailed knowledge exists on DNA methylation composition but not its variability.
    • Understanding DNA methylation variability is critical for gene regulation, genome evolution, and adaptation.
    • Further research is needed to elucidate the functional impact of DNA methylation variation.