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In vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureus
Kevin W McConeghy1, Kerry L LaPlante
1Department of Pharmacy Practice, University of Rhode Island, Veterans Affairs Medical Center (151), Providence, RI 02908, USA.
Abstract:
We investigated the activity of tigecycline in combination with gentamicin for the treatment of biofilm-forming methicillin-resistant and sensitive Staphylococcus aureus in an in vitro pharmacodynamic model. Tigecycline monotherapy demonstrated bacteriostatic activity throughout 48 h (-0.24 +/- 0.17 log(10) CFU/mL), whereas tigecycline in combination with gentamicin demonstrated significant (P < 0.002) kill (-3.66 +/- 0.26 log(10) CFU/mL) at 48 h. The addition of gentamicin to tigecycline significantly improved the killing activity of tigecycline in biofilm-forming S. aureus.
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