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Updated: Jun 10, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its
Takumi Watanabe1, Ikuko Kurata, Chigusa Hayashi
1Institute of Microbial Chemistry Tokyo 141-0021, Japan. twatanabe@bikaken.or.jp
Abstract:
A synthetic route to paleic acid 1, antimicrobial agent effective against Mannheimia haemolytica and Pasteurella multocida, has been established. The absolute configuration of the secondary hydroxyl group was controlled by a catalytic asymmetric alkylation of an aldehyde using a chiral titanium sulfonamide complex and the cis double bond was installed using a Wittig reaction. This synthetic route was also applied to the preparation of structurally related analogs, which were used in structure-activity relationship studies for antibacterial activity.
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