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Updated: Jun 10, 2026

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
Published on: December 1, 2015
Partial area of cholesterol in monounsaturated diacylphosphatidylcholine bilayers
J Gallová1, D Uhríková, N Kučerka
1Department of Physical Chemistry of Drugs, Comenius University in Bratislava, Slovakia. gallova@fpharm.uniba.sk
Abstract:
The influence of cholesterol on the structural parameters of phosphatidylcholine bilayers is studied by small-angle neutron scattering on unilamellar liposomes. Monounsaturated diacylphosphatidylcholines diCn:1PC with the length of acyl chains n=14, 18 and 22 carbons are used. We confirm that the bilayer thickness increases with increasing concentration of cholesterol for all studied diCn:1PCs. However, partial areas per diCn:1PC and cholesterol molecule on lipid-water interface are found not to depend of cholesterol concentration. The partial area per cholesterol molecule is 0.24nm². In addition, the partial area per diC18:1PC is larger than that for diC14:1PC and diC22:1PC.
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