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Updated: Jun 10, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
Propylene glycol and contact-lens solutions containing this diol induce pseudocyst formation in acanthamoebae
Jarmila Kliescikova1, Jaroslav Kulda, Eva Nohynkova
1Department of Tropical Medicine, 1st Medical Faculty, Charles University in Prague, Faculty Hospital Bulovka, 128 00 Prague, Czech Republic.
Abstract:
Propylene glycol used as an ophthalmic demulcent in certain contact-lens care systems has been included recently among factors responsible for increasing Acanthamoeba keratitis. In this study, we provide evidence that propylene glycol as well as examined contact-lens solutions containing it induce rapid differentiation of acanthamoebae into pseudocysts. The partial resistance of the pseudocysts and their reversibility to viable trophozoites even after 24-h exposure to the contact-lens solutions indicate a potential risk of infection to contact-lens users.
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