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Related Experiment Video

Updated: Jun 10, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

dSir2 and longevity in Drosophila.

Stewart Frankel1, Tahereh Ziafazeli, Blanka Rogina

  • 1Department of Biology, University of Hartford, West Hartford, CT, 06117, USA.

Experimental Gerontology
|August 24, 2010
PubMed
Summary

Silent Information Regulator 2 (Sirtuin) proteins extend longevity across species. This review explores how Drosophila Sir2 (dSir2) links caloric restriction, resveratrol, and aging pathways.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • The Silent Information Regulator 2 (Sirtuin) protein family is conserved across species and linked to longevity.
  • Sirtuins influence critical physiological processes, including metabolism, stress response, and aging.
  • Caloric restriction (CR) extends lifespan and delays age-related diseases in many organisms.

Purpose of the Study:

  • To review the role of Drosophila Sir2 (dSir2) in longevity regulation.
  • To examine the connection between dSir2, caloric restriction (CR), and aging pathways in Drosophila.
  • To discuss the impact of the Sirtuin activator resveratrol and potential dSir2-p53 interactions.

Main Methods:

  • Literature review of studies on Sirtuins, Drosophila, caloric restriction, resveratrol, and p53.
  • Analysis of evidence linking dSir2 to longevity and CR pathways.
  • Examination of research on resveratrol's effects and dSir2-p53 interactions.

Main Results:

  • Drosophila Sir2 (dSir2) is implicated in mediating some beneficial effects of caloric restriction (CR).
  • Evidence suggests a role for dSir2 in regulating longevity in response to CR.
  • Resveratrol, a Sirtuin activator, may interact with dSir2 and p53, influencing aging.

Conclusions:

  • Drosophila Sir2 (dSir2) plays a significant role in the longevity effects of caloric restriction (CR).
  • Further research into the interactions between dSir2, resveratrol, and p53 could reveal new aging interventions.
  • Sirtuins represent a key target for understanding and potentially modulating the aging process.

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Last Updated: Jun 10, 2026

Measurement of Lifespan in Drosophila melanogaster
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