Related Experiment Video
Updated: Jun 10, 2026
05:55
Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
Published on: June 17, 2025
[Influence of paternal age]
J-F Velez de la Calle1, B Broussin, C Lelaidier
1Unité FIV, Clinique Pasteur, 34, Rue du Moulin à Poudre, Brest, France.
Insights
Advanced paternal age is linked to increased risks of miscarriage, birth defects, and developmental disorders like autism, schizophrenia, and bipolar disorder in offspring. This highlights the importance of parental age in reproductive health outcomes.
Area of Science:
- Reproductive medicine and genetics.
- Developmental neuroscience and psychiatry.
Context:
- Increasing paternal age is a growing concern in reproductive health.
- Paternal age-related risks are distinct from maternal age effects.
Purpose:
- To investigate the association between advanced paternal age and adverse child health outcomes.
- To quantify the risks of miscarriage, malformations, and neurodevelopmental disorders with increasing paternal age.
Summary:
- Higher paternal age correlates with elevated risks of spontaneous abortion (miscarriage).
- Advanced paternal age is associated with a higher incidence of congenital malformations.
- Increased paternal age is a significant risk factor for autism spectrum disorder, schizophrenia, and bipolar disorder in children.
Impact:
- Informs genetic counseling and reproductive planning for older fathers.
- Highlights the need for further research into the biological mechanisms underlying paternal age effects.
- Contributes to understanding the etiology of neurodevelopmental and psychiatric disorders.
Abstract:
Father's age increase miscarriage, malformation, risk of autism, schizophrenia, and bipolar troubles in children.
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:23Influence of Parents and Peers on Identity
Adolescence is a pivotal period of identity formation, during which individuals begin to answer questions central to their sense of self, such as "Who am I?" and "Who do I hope to become?" Both parents and peers play critical roles in guiding adolescents through this complex developmental phase.
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth. This guiding role...
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth. This guiding role...
01:17Two-Way ANOVA
The two-way ANOVA is an extension of the one-way ANOVA. It is a statistical test performed on three or more samples categorized by two factors - a row factor and a column factor. Ronald Fischer mentioned it in 1925 in his book 'Statistical Methods for Researchers.'
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the means for...
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the means for...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...