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Targeted laryngeal photodynamic therapy with a balloon diffusing light source.

Craig Grossman¹, Timothy Zhu, Jarod Finlay

¹Department of Radiation Oncology, University of Pennsylvania, PA, USA.

Photodiagnosis and Photodynamic Therapy

|August 24, 2010

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Photodynamic therapy (PDT) using a novel balloon catheter effectively treated laryngeal dysplasia. This technique offers a promising, low-toxicity option for anterior glottic lesions.

Area of Science:

Otolaryngology
Oncology
Medical Devices

Background:

Photodynamic therapy (PDT) is utilized for pre-malignant mucosal lesions.
Recurrent high-grade dysplasia in the glottic larynx presents treatment challenges.

Observation:

A patient with glottic dysplasia required an alternative to standard microlens fibers for PDT light delivery.
A 2-cm translucent diffusing balloon catheter was employed to deliver photoactivating light.

Findings:

The balloon catheter facilitated light delivery to the targeted lesion.
Real-time measurements showed stable photobleaching.
Light scatter from the balloon diffuser augmented light fluence in adjacent areas.

Implications:

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The balloon catheter represents a potential new application for PDT.
This method may be advantageous for treating anterior glottic lesions.
The technique demonstrated minimal acute toxicity.