Related Experiment Video
Updated: Jun 10, 2026

Assaying the Kinase Activity of LRRK2 in vitro
Published on: January 18, 2012
LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation
Makoto Kubo1, Yoshiko Kamiya, Ryuichi Nagashima
1Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan.
Abstract:
LRRK2, the causal molecule of familial Parkinson's disease, is expressed strongly by one of the B cell subsets, B-2 cells, but not by the other subset, B-1 cells, in the mouse peritoneal cavity, spleen, and peripheral blood. Bone marrow pre-B cells or T cells exhibited little LRRK2 expression. LRRK2 expression was dramatically downregulated upon activation of B-2 cells with various types of stimulation. These results suggest that LRRK2, whose true function has not yet been clarified, may play some important role(s) in the development and function of B cells, particularly the maintenance of B-2 cells in a resting status.
Related Concept Videos
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Cell Signaling in Plants
The Intrinsic Apoptotic Pathway
Receptor Tyrosine Kinases
Negative Regulator Molecules
