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Related Experiment Video

Updated: Jun 10, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia.

Michael P Robich¹, Robert M Osipov, Louis M Chu

¹Department of Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI, USA.

Journal of the American College of Surgeons

|August 24, 2010

Summary

This summary is machine-generated.

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Chronic myocardial ischemia in pigs showed improved cardiac function and blood vessel growth over time. Angiogenesis signaling and cell survival markers increased, indicating natural recovery processes.

Area of Science:

Cardiovascular Research
Myocardial Ischemia
Angiogenesis

Background:

Chronic myocardial ischemia impairs cardiac function and blood supply.
Understanding the temporal progression of cardiac response is crucial for therapeutic development.

Purpose of the Study:

To investigate the time-dependent changes in cardiac function.
To assess the spatial progression of angiogenesis signaling in a porcine model of chronic myocardial ischemia.

Main Methods:

Chronic myocardial ischemia was induced in Yorkshire mini-swine using an ameroid constrictor.
Cardiac function, angiogenesis, microvessel function, molecular signaling, apoptosis, and oxidative stress were evaluated at 4 and 7 weeks post-induction.

Main Results:

Related Experiment Videos

Last Updated: Jun 10, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Improved myocardial function and increased flow reserve were observed at 7 weeks compared to 4 weeks.
Vascular endothelial growth factor (VEGF) and phospho-endothelial nitric acid synthase (eNOS) expression increased, while apoptosis markers decreased.
Enhanced microvessel function and increased endothelial cell proliferation were noted over time.

Conclusions:

Cardiac function, myocardial perfusion, and angiogenic signaling show improvement over time following coronary occlusion.
The porcine model demonstrates a natural recovery process in response to chronic myocardial ischemia.