Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it produces...
Dose Response Curve: Conventional Versus Nonmonotonic01:21

Dose Response Curve: Conventional Versus Nonmonotonic

The correlation between a drug's dosage and its impact on a biological system is a cornerstone of pharmacology and toxicology. Conventional dose–response curves, which include graded and quantal relationships, are key to this understanding. Graded dose–response curves depict the spectrum of a biological reaction to different doses within an individual, indicating that as the drug dosage increases, so does the intensity of the response. On the other hand, quantal dose–response relationships...
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of clinical trial radiotherapy quality assurance: value, evolution and lessons.

Clinical and translational radiation oncology·2026
Same author

Label-free live characterization of mesenchymal stem cell spheroids by biophysical properties measurement.

Advances in biological regulation·2024
Same author

[Does radiation therapy for prostate cancer increase the risk of second cancers?]

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

[Informed consent in radiotherapy care].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

[Characteristics of radiotherapy for adolescents and young adults].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

Stereotactic magnetic resonance imaging-guided radiotherapy for intracardiac metastases: A case report.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024

Related Experiment Video

Updated: Jun 10, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

["Dose-painting": myth or reality?].

S Supiot1, A Lisbona, F Paris

  • 1Service de Radiothérapie, Centre René-Gauducheau, Boulevard Jacques-Monod, 44800 Nantes-St-Herblain, France. s-supiot@nantes.fnclcc.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|August 24, 2010
PubMed
Summary

Dose-painting radiotherapy uses functional imaging to target radioresistant tumor areas with higher radiation doses. While challenging for routine use, this biology-guided approach is a key future direction for radiation oncology.

More Related Videos

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints
08:42

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints

Published on: August 29, 2014

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Related Experiment Videos

Last Updated: Jun 10, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints
08:42

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints

Published on: August 29, 2014

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Radiation Oncology
  • Medical Imaging
  • Cancer Biology

Background:

  • Radiotherapy can be improved by targeting radioresistant tumor sub-volumes.
  • Functional imaging identifies these biologically distinct areas within tumors.
  • Dose-painting delivers escalated doses to these identified radioresistant regions.

Purpose of the Study:

  • To review the biological basis of radioresistance and its imaging.
  • To detail intensity-modulated radiation therapy (IMRT) techniques for dose-painting.
  • To present clinical outcomes of dose-painting in various cancers.

Main Methods:

  • Literature review of radioresistance mechanisms and imaging modalities.
  • Description of IMRT planning and delivery for heterogeneous dose distributions.
  • Synthesis of clinical data from studies on head and neck, prostate, and brain tumors.

Main Results:

  • Biological targets (biological target volume [BTV]) can be defined using functional imaging.
  • IMRT enables dose escalation to BTVs within the gross tumor volume.
  • Clinical results show potential but highlight current technical and practical challenges.

Conclusions:

  • Dose-painting IMRT is a promising biology-guided radiotherapy strategy.
  • Current implementation faces significant technical and clinical hurdles.
  • This approach represents a major future development pathway in radiation therapy.