Related Experiment Video

Updated: Jun 10, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Clinical features of echovirus 6 and 9 infections in children

Hao-Yuan Lee1, Chih-Jung Chen, Yhu-Chering Huang

  • 1Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|August 24, 2010
PubMed

Insights

Clinical features of echovirus 6 and 9 infections in children were evaluated. Aseptic meningitis was most common, but rare severe outcomes like death or seizures can occur in hospitalized children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Clinical manifestations of echovirus 6 and 9 infections in children, especially sporadic cases, require further evaluation.
  • Understanding these features is crucial for timely diagnosis and management.

Purpose of the Study:

  • To comprehensively describe the clinical spectrum of echovirus 6 and 9 infections in pediatric patients.
  • To identify differences in clinical presentation and outcomes between echovirus 6 and 9 infections.

Main Methods:

  • A retrospective analysis of 199 children with culture-proven echovirus 6 or 9 infections from 2000-2008.
  • Detailed data extraction and analysis focused on 174 hospitalized children.

Main Results:

  • Aseptic meningitis was the most frequent diagnosis for both echovirus 6 (49%) and 9 (51%) infections.
  • Echovirus 9 infections were associated with longer fever duration (6.0 vs. 3.8 days) and echovirus 6 with higher leukocytosis rates.
  • While most children recovered, rare severe outcomes including death and seizure disorders were observed.

Conclusions:

  • Aseptic meningitis is the predominant clinical presentation for hospitalized children with echovirus 6 or 9 infections.
  • Although uncommon, severe complications such as mortality and long-term neurological sequelae can occur.
  • This study highlights the importance of recognizing the diverse clinical spectrum of these viral infections in children.
Abstract

More Related Videos

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...