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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Updated: Jun 10, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Large non-coding RNAs: missing links in cancer?

Maite Huarte1, John L Rinn

  • 1The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Human Molecular Genetics
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

Large non-coding RNAs (lncRNAs) are crucial regulators of cellular balance, impacting cancer development. Understanding lncRNAs offers potential for new cancer biomarkers and therapies.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

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Last Updated: Jun 10, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Cellular homeostasis relies on balanced regulatory networks; disruption leads to transformation.
  • Proteins and non-coding RNAs (ncRNAs) coordinate cellular circuits.
  • Large ncRNAs (lncRNAs) are increasingly recognized as key regulators in cancer pathways.

Purpose of the Study:

  • To synthesize recent advances in understanding the mechanistic roles of lncRNAs in regulating cellular equilibrium.
  • To highlight lncRNAs as emerging oncogenic and tumor-suppressor genes.
  • To explore the potential of lncRNAs as future biomarkers and therapeutic targets in cancer.

Main Methods:

  • Literature review and synthesis of recent studies on lncRNA mechanisms in cancer.
  • Analysis of lncRNA roles at transcriptional, post-transcriptional, and epigenetic levels.
  • Integration of findings within the context of cellular homeostasis and transformation.

Main Results:

  • lncRNAs play significant roles in regulating key cancer pathways.
  • Mechanistic insights reveal lncRNA involvement in transcriptional, post-transcriptional, and epigenetic regulation.
  • lncRNAs function similarly to protein-coding genes as oncogenes or tumor suppressors.

Conclusions:

  • lncRNAs are critical regulators of cellular equilibrium and transformation.
  • lncRNAs represent a novel class of oncogenic and tumor-suppressor genes.
  • lncRNAs hold promise as future biomarkers and therapeutic targets for cancer treatment.