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Updated: Jun 10, 2026
09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Current insights into ocular graft-versus-host disease
Anjo Riemens1, Liane te Boome, Saskia Imhof
1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. J.A.Riemens@umcutrecht.nl
Current Opinion in Ophthalmology
|August 24, 2010
Summary
Hematopoietic stem cell transplantation (SCT) can lead to ocular graft-versus-host disease (GVHD) in many patients. Current treatments offer limited relief, highlighting the need for better therapeutic and preventive strategies for this severe ocular complication.
Area of Science:
- Hematology
- Ophthalmology
- Immunology
Background:
- Allogeneic hematopoietic stem cell transplantation (SCT) is increasingly used for hematological disorders.
- Ocular graft-versus-host disease (GVHD) affects 40-60% of patients post-SCT, severely impacting ocular surface and quality of life.
- Established treatment guidelines for ocular GVHD are lacking.
Purpose of the Study:
- To provide an updated overview of hematopoietic stem cell transplantation (SCT) and graft-versus-host disease (GVHD).
- To summarize current and novel treatment strategies for ocular GVHD.
Main Methods:
- Literature review of current data on ocular GVHD.
- Focus on novel treatment options and existing therapies.
Main Results:
- Ocular GVHD is a common and debilitating complication of allogeneic SCT.
- Current treatments include artificial tears, topical steroids, punctal occlusion, contact lenses, topical cyclosporine A, and tacrolimus.
- No treatment regimen is fully satisfactory, and efficacy data are limited.
- Preventive measures for ocular GVHD remain undefined.
Conclusions:
- Ocular GVHD is a severe complication requiring further research.
- Novel therapeutic and preventive strategies for ocular GVHD are needed.
- More data are required on the impact of ocular GVHD and the efficacy of interventions.
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