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Related Experiment Video

Updated: Jun 10, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Isoflavones decrease insomnia in postmenopause.

Helena Hachul¹, Letícia Campos Brandão, Vânia D'Almeida

¹Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil. helenahachul@psicobio.epm.br

Menopause (New York, N.Y.)

|August 24, 2010

Summary

Isoflavone treatment significantly improved sleep efficiency and reduced insomnia symptoms in postmenopausal women. This study confirms isoflavones as an effective intervention for menopausal insomnia.

Related Experiment Videos

Last Updated: Jun 10, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Area of Science:

Menopause Research
Sleep Medicine
Phytohormone Studies

Background:

Postmenopausal insomnia is prevalent, often co-occurring with other sleep disturbances.
Isoflavones, a type of phytohormone, show potential in alleviating menopausal symptoms.

Purpose of the Study:

To evaluate the effects of isoflavone treatment on subjective and objective sleep parameters in postmenopausal women with insomnia.
To assess changes in sleep quality and menopausal symptoms during isoflavone therapy.

Main Methods:

A controlled, double-blind study involving postmenopausal women with insomnia.
Participants received either 80 mg of isoflavones daily or a placebo for 4 months.
Sleep was assessed using questionnaires and polysomnography; statistical analyses included t-tests, ANOVA, and Pearson's correlation.

Main Results:

The isoflavone group showed a significant increase in sleep efficiency (77.9% to 83.9%) compared to the placebo group (77.6% to 81.2%).
Isoflavones reduced the intensity and frequency of hot flashes and decreased insomnia prevalence.
Insomnia severity decreased substantially in the isoflavone group (89.5% to 36.9%) versus the placebo group (94.7% to 63.2%).

Conclusions:

Isoflavone treatment effectively reduced insomnia symptoms in postmenopausal women.
Polysomnographic analysis confirmed improved sleep efficiency, supporting isoflavones as a beneficial intervention.