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Related Experiment Video

Updated: Jun 10, 2026

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Caloric restriction and heart function: is there a sensible link?

Xuefeng Han¹, Jun Ren

¹Department of Physiology, Fourth Military Medical University, Xi'an, China.

Acta Pharmacologica Sinica

|August 24, 2010

Summary

Calorie restriction (CR) may slow aging and prevent cardiovascular disease by triggering beneficial cellular adaptations. However, practical challenges and health concerns limit its widespread clinical use for heart health.

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

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Published on: November 27, 2019

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Last Updated: Jun 10, 2026

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Area of Science:

Cardiology
Gerontology
Metabolic research

Background:

Calorie restriction (CR) involves reducing calorie intake without malnutrition.
CR demonstrates potential in retarding aging and cardiovascular disease.
Mechanisms include reduced reactive oxygen species and inflammation.

Purpose of the Study:

To review the cardiac consequences of CR.
To discuss CR's safety and efficacy in cardiovascular health management.

Main Methods:

Review of existing clinical and experimental evidence.
Discussion of biochemical and cellular adaptations.

Main Results:

CR shows favorable cardiovascular effects, potentially mediated by redox homeostasis, mitochondrial function, inflammation, apoptosis, and autophagy.
CR may retard aging and cardiovascular disease progression.

Conclusions:

CR presents potential benefits for cardiovascular health.
Applicability issues and health concerns currently hinder CR implementation in healthcare.