Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic value of tumor dissemination feature based on baseline 18 F-FDG PET/CT in patients with newly diagnosed multiple myeloma.

Nuclear medicine communications·2025
Same author

Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer.

World journal of gastrointestinal oncology·2025
Same author

Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment.

Journal of ethnopharmacology·2025
Same author

[The Influence of COVID-19 Infection on the Mobilization and Collection of Autologous Peripheral Blood Stem Cells in Patients with Multiple Myeloma].

Zhongguo shi yan xue ye xue za zhi·2025
Same author

Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension.

World journal of cardiology·2024
Same author

The Dopamine Transporter Is a New Target for Ischemic Stroke.

CNS neuroscience & therapeutics·2024
Same journal

Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies.

Acta pharmacologica Sinica·2026
Same journal

Targeting BCL9/BCL9L enhances CD4<sup>+</sup> T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling.

Acta pharmacologica Sinica·2026
Same journal

TGF-β2 signaling promotes cardiac fibrosis in arrhythmogenic right ventricular cardiomyopathy mediated by DSC2 deficiency.

Acta pharmacologica Sinica·2026
Same journal

Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure.

Acta pharmacologica Sinica·2026
Same journal

Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics.

Acta pharmacologica Sinica·2026
Same journal

Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems.

Acta pharmacologica Sinica·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Genetics of stroke.

Jin-min Guo1, Ai-jun Liu, Ding-feng Su

  • 1Department of Pharmacology, Second Military Medical University, Shanghai, China.

Acta Pharmacologica Sinica
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

Stroke genetics involve complex environmental and genetic factors. In vivo animal models are crucial tools for understanding the genetic basis of stroke and its contributing pathways.

More Related Videos

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jun 10, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Stroke is a leading cause of death and disability globally.
  • It is a multifactorial disease influenced by both environmental and genetic factors.
  • Epidemiological studies indicate a significant genetic component in stroke occurrence.

Purpose of the Study:

  • To review the role of in vivo stroke models in studying stroke genetics.
  • To explore candidate genes involved in lipid metabolism, thrombosis, and inflammation.
  • To address conflicting results from epidemiological studies on stroke genetics.

Main Methods:

  • Review of existing literature on stroke genetics.
  • Analysis of studies investigating candidate genes related to stroke.
  • Examination of progress in studying stroke as a monogenic disease.
  • Focus on the utility of animal models in genetic stroke research.

Main Results:

  • Conflicting results exist for many candidate genes studied in relation to stroke.
  • Significant progress has been made in understanding monogenic forms of stroke.
  • In vivo animal models are essential for dissecting complex stroke genetics.

Conclusions:

  • In vivo stroke models are indispensable tools for advancing the understanding of stroke genetics.
  • Further research using these models can clarify the genetic underpinnings of stroke.
  • Elucidating genetic factors is key to addressing stroke as a major health issue.