Dronedarone for the treatment of atrial fibrillation and atrial flutter: approval and efficacy

Deborah Wolbrette1, Mario Gonzalez, Soraya Samii

  • 1Penn State Heart and Vascular Institute, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033-0850, USA. dwolbrette@hmc.psu.edu

Insights

Dronedarone, an antiarrhythmic drug, is approved for atrial fibrillation, reducing mortality and hospitalizations. It

Area of Science:

  • Pharmacology
  • Cardiology
  • Electrophysiology

Background:

  • Dronedarone is a Class III antiarrhythmic agent approved for atrial fibrillation and atrial flutter.
  • It is an analog of amiodarone, sharing multichannel blocking properties but lacking iodine, potentially reducing toxicity.
  • Previous trials like ANDROMEDA raised safety concerns in specific heart failure populations.

Purpose of the Study:

  • To evaluate the efficacy and safety of dronedarone in patients with atrial fibrillation or atrial flutter.
  • To compare dronedarone with amiodarone regarding efficacy in maintaining sinus rhythm and adverse event profiles.

Main Methods:

  • Analysis of data from the ATHENA trial, including post hoc assessments.
  • Consideration of preliminary data from the DIONYSOS trial.
  • Indirect meta-analysis comparing dronedarone and amiodarone.

Main Results:

  • The ATHENA trial demonstrated significant reductions in all-cause mortality and cardiovascular hospitalizations with dronedarone.
  • A post hoc analysis suggested a potential decrease in stroke risk.
  • Dronedarone showed fewer adverse effects leading to early drug termination compared to amiodarone, though amiodarone was more effective in maintaining sinus rhythm.

Conclusions:

  • Dronedarone is the first antiarrhythmic drug for atrial fibrillation/flutter proven to reduce cardiovascular hospitalizations.
  • It is recommended for patients with structural heart disease (ejection fraction >35%) without recent decompensated heart failure.
  • Dronedarone may be considered earlier in the treatment algorithm than amiodarone in eligible patients.

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