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Updated: Jun 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Organocatalytic synthesis of spiro compounds via a cascade Michael-Michael-aldol reaction
Xavier Companyó1, Alex Zea, Andrea-Nekane R Alba
1Department de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain.
Abstract:
The synthesis of spiro compounds via a Michael-Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities.
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