Related Experiment Video
Updated: Jun 10, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
An indolent diffuse infiltrating gastric carcinoma
V H Chong1, P U Telisinghe, S K Yapp
1Gastroenterology Unit, Department of Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, BA 1710, Brunei Darussalam. chongvuih@yahoo.co.uk
Abstract:
Gastric cancer is a common gastrointestinal cancer and is an important cause of cancer mortality. Unfortunately, it is often diagnosed late due to delayed presentation. We report the case of a 48-year-old man who was diagnosed with diffuse infiltrating gastric adenocarcinoma and who had initially declined surgery. The patient presented again the following year, and the repeat evaluations showed similar findings. Despite this, the patient continued to decline interventions. Six years later, as his symptoms increased, the patient finally underwent surgery. Histology revealed a diffuse infiltrating stage T3 tumour, with significant desmoplastic reaction and negative lymphadenopathies. Seven years after the surgery, the patient remained well and recurrence-free. This case highlights that some cancers have an indolent course, and even with significant delay, curative interventions can still be performed.
Related Concept Videos
Gastritis II: Pathophysiology
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastric Motility
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...