Related Experiment Video
Updated: Jun 10, 2026
05:31
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
VIPoma syndrome: challenges in management
1Endocrine Unit, Department of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Malaysia.
Singapore Medical Journal
|August 24, 2010
Summary
Vasoactive intestinal peptide-producing tumors (VIPomas) are rare neuroendocrine tumors. Surgical resection offers curative potential for localized disease, while somatostatin analogues manage symptoms in advanced cases.
Area of Science:
- Endocrinology
- Surgical Oncology
- Gastroenterology
Background:
- Vasoactive intestinal peptide-producing tumor (VIPoma) is a rare neuroendocrine tumor, often originating in the pancreas.
- VIPoma syndrome, or Verner-Morrison syndrome, is characterized by delayed diagnosis and hormone-mediated symptoms.
Observation:
- A female patient presented with a metastatic VIPoma involving the liver at diagnosis.
- The patient underwent palliative Whipple procedure and radiofrequency ablation for liver metastases.
Findings:
- Initial treatment provided symptomatic relief for three years before disease progression.
- Current management involves daily octreotide therapy, achieving partial symptom control.
Implications:
- This case highlights the challenges in managing metastatic VIPoma.
- Somatostatin analogue therapy plays a crucial role in long-term symptom management for advanced neuroendocrine tumors.
Related Concept Videos
01:28Pleural Effusion II: Symptoms and Management
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:24Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:19Mitral Valve Prolapse III: Nursing Management
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...