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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Outcome of protracted hypoparathyroidism after total thyroidectomy
A Sitges-Serra1, S Ruiz, M Girvent
1Endocrine Surgery Unit, Hospital Universitari del Mar, Barcelona, Spain. asitges@hospitaldelmar.cat
The British Journal of Surgery
|August 24, 2010
Summary
Persistent hypoparathyroidism (HPP) after thyroidectomy is common. Intensive medical treatment, including calcium and calcitriol, may improve parathyroid function recovery in patients with HPP.
Area of Science:
- Endocrinology
- Surgical Oncology
Background:
- Post-thyroidectomy hypocalcaemia is a known complication.
- Risk factors and long-term outcomes of persistent hypoparathyroidism (HPP) require further definition.
Purpose of the Study:
- To investigate risk factors for protracted HPP after total thyroidectomy.
- To evaluate the long-term outcome of HPP and identify factors associated with parathyroid function recovery.
Main Methods:
- Retrospective review of a prospective protocol for managing post-thyroidectomy hypocalcaemia.
- Patients with serum calcium < 8 mg/dl 24h post-thyroidectomy received oral calcium with or without calcitriol.
- Protracted HPP defined as intact parathyroid hormone (iPTH) < 13 pg/ml and need for calcium at 1 month; followed for at least 1 year.
Main Results:
- 50.2% of 442 patients developed postoperative hypocalcaemia.
- 80 patients developed protracted HPP, associated with lymphadenectomy, fewer than three glands left in situ, and incidental parathyroidectomy.
- Parathyroid function recovered within 1 year in 78% of patients with protracted HPP; higher serum calcium and detectable iPTH at 1 month predicted late recovery.
Conclusions:
- Higher serum calcium levels at 1 month post-thyroidectomy correlate with parathyroid function recovery.
- Intensive medical management ('parathyroid splinting') may enhance outcomes for protracted HPP.
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