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DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA Isolation

DNA Isolation

DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further processing. For example, plasmid DNA extraction is a bit more complicated than genomic DNA extraction because of the need for an appropriate lysis method to separate plasmid DNA from gDNA during isolation. However, for specific applications, such as long-range DNA sequencing that require a good yield of high- quality DNA samples, we need to follow...

DNA Isolation

DNA Isolation

DNA from cells is required for many biotechnology and research applications, such as molecular cloning. To remove and purify DNA from cells, researchers use various methods of DNA extraction. While the specifics of different protocols may vary, some general concepts underlie the process of DNA extraction.

Complementary DNA

Complementary DNA

Complementary DNA

Complementary DNA

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Related Experiment Video

Updated: Jun 10, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Novel DNA materials and their applications.

Dayong Yang¹, Michael J Campolongo, Thua Nguyen Nhi Tran

¹Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|August 24, 2010

Summary

DNA is a versatile nanomaterial building block, enabling the creation of advanced nanostructures and bulk materials. These novel DNA materials offer significant potential for applications in nanomedicine and the broader biomedical field.

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Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Deoxyribonucleic acid (DNA) has evolved beyond its genetic role to become a key material in nanotechnology.
Its inherent properties—biological function, nanoscale structure, biocompatibility, and molecular recognition—make it ideal for advanced material construction.

Purpose of the Study:

To review the advancements in DNA-based nanomaterials and their applications.
To highlight the development of multifunctional and bulk DNA materials.
To discuss the current and future directions of DNA materials in nanomedicine.

Main Methods:

Review of scientific literature on DNA self-assembly and material fabrication.
Analysis of DNA's role in constructing nanostructures (lattices, origami, 3D objects) and directing the assembly of other nanomaterials.
Exploration of DNA's use as a structural component in bulk materials like hydrogels.

Main Results:

DNA is a versatile building block for diverse nanostructures and functional materials.
DNA acts as a template for assembling other nanomaterials, including nanowires and crystals.
DNA can form bulk materials, such as hydrogels, showcasing its polymeric nature.

Conclusions:

Novel DNA materials demonstrate significant promise for biomedical and nanomedical applications.
Continued research into DNA assemblies and bulk materials will drive innovation in nanomedicine.