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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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NOTCH1 mutation in a female with myeloid/NK cell precursor acute leukemia

Norio Shiba1, Takashi Kanazawa, Myoung-ja Park

  • 1Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. nshiba@showa.gunma-u.ac.jp

Pediatric Blood & Cancer
|August 24, 2010
PubMed

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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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