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Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

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Updated: Jun 10, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Nanostructured bladder tissue replacements.

Young Wook Chun¹, Hojean Lim², Thomas J Webster¹

¹Division of Engineering, Brown University, Providence, RI, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|August 24, 2010

Summary

Nanostructured biomaterials enhance bladder tissue regeneration by improving cell interactions and reducing stone formation. These advanced materials offer promising solutions for tissue engineering and regenerative medicine applications.

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Area of Science:

Biomaterials Science
Tissue Engineering
Nanotechnology

Background:

Cell-material interactions are crucial for tissue engineering.
Surface properties of biomaterials significantly influence cellular responses.
Nanotechnology offers methods to optimize biomaterial surfaces for regenerative medicine.

Purpose of the Study:

To review the importance of nanostructured biomaterial surfaces for bladder tissue replacements.
To discuss future directions in nanostructured biomaterials for bladder regeneration.

Main Methods:

Review of in vivo and in vitro studies on bladder tissue growth on polymeric surfaces.
Correlation of cell responses to nanomaterial surface features and surface energy.
Analysis of cell adhesion, proliferation, and calcium stone formation.

Main Results:

Nanoscale to submicron surface features on polymers promote greater bladder tissue growth.
Nanostructured polymers exhibit improved bladder cell adhesion and proliferation compared to conventional polymers.
Unique nanomaterial surface features influence protein interactions and decrease calcium stone formation.

Conclusions:

Nanostructured biomaterial surfaces are vital for effective bladder tissue engineering.
Optimized surface features enhance cell integration and reduce adverse effects like stone formation.
This field holds significant promise for future regenerative medicine applications.