Related Experiment Video
Updated: Jun 10, 2026
Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013
[Expression of B7-H4 in prostate cancer and its clinical significance]
Yun Qian1, Hang-ping Yao, Ling Shen
1Institute of Immunology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Objective:
To investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.
Methods:
Immunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue. And the relationship between the expressions and pathology was evaluated.
Results:
The B7-H4 was diffusely expressed in cytoplasm and/or membrane of the prostate cancer tissue; the expression was much higher than that in normal prostate tissue (P<0.05). The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.
Conclusion:
B7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.
