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[24-hour antihypertensive efficacy of nitrendipine]
N Spritzer1, C M Medeiros, T S Spritzer
1Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, RS.
Purpose:
To evaluate the efficacy of nitrendipine 20 mg OD in mild to moderate hypertensive subjects.
Patients And Methods:
Twenty patients followed for 90 days. The protocol was a double blind placebo control trial using 24 hours ambulatory blood pressure monitoring system for pressure and heart rate observations. After 15 days without any drug patients were randomly assigned to the study divided into two subgroups: one remained 30 days using placebo and the other nitrendipine. After a new 15 days washout period there was a cross over of the study groups and then other 30 days of follow-up.
Results:
The 24 hours mean systolic blood pressure decreased (p less than 0.0001) with nitrendipine (127.7 +/- 8 mmHg) in relation to placebo (139.2 +/- 8 mmHg); the mean diastolic blood pressure decreased (p less than 0.0001) with nitrendipine (84.6 +/- 4 mmHg) in relation to placebo (90.7 +/- 5 mmHg). There were no significant changes on heart rate and body weight.
Conclusion:
Nitrendipine seems to be a safe and efficient antihypertensive agent for 24 hours blood pressure control. The drug can decrease blood pressure levels without significant changes over the circadian pattern of the 24 hours blood pressure curve and without unwanted drop of blood pressure levels.