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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training
09:57

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Published on: January 18, 2021

Individualized medicine 2010.

Hubert E Blum1

  • 1Department of Medicine II, University Hospital Freiburg, Germany. hubert.blum@uniklinik-freiburg.de

Journal of Cellular and Molecular Medicine
|August 25, 2010
PubMed
Summary
This summary is machine-generated.

Molecular and cell biology advances enable precise disease risk assessment and prognosis prediction. These methods pave the way for personalized medicine, tailoring treatments to individual genetic profiles.

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genomics

Background:

  • Molecular and cell biology have transformed disease diagnosis, therapy, and prevention.
  • Understanding disease pathogenesis has been significantly advanced by these fields.

Purpose of the Study:

  • To address recent advances in predictive medicine and their clinical relevance.
  • To highlight the role of molecular diagnostics in personalized healthcare.

Main Methods:

  • Utilizing modern molecular and biochemical techniques to identify genetic variations like point mutations and single nucleotide polymorphisms.
  • Employing high-throughput array technologies for simultaneous analysis of thousands of genes or gene products, creating gene expression profiles (signatures).

Main Results:

  • Gene expression profiles enable the definition of individual disease risk.
  • These signatures aid in predicting disease prognosis and therapeutic strategy efficacy.

Conclusions:

  • Predictive medicine, driven by molecular insights, is crucial for individualized treatment strategies.
  • Advances in analyzing genetic and gene expression profiles are key to the future of personalized healthcare.