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Selective tricuspidization and aortic cusp extension valvuloplasty: outcome analysis in infants and children
Anastasios C Polimenakos1, Shyam Sathanandam, Christopher Blair
1Division of Pediatric Cardiovascular Surgery, The Heart Institute for Children at Advocate Hope Children's Hospital, Oak Lawn, Illinois, USA. anastasios_c_polimenakos@rush.edu
Insights
Aortic cusp extension valvuloplasty is a durable, nonreplacement strategy for children with aortic valve disease, offering good long-term freedom from aortic valve replacement (AVR). This technique facilitates left ventricular reverse remodeling in pediatric patients.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Cardiac Surgery
Background:
- Emerging aortic cusp extension valvuloplasty techniques offer nonreplacement strategies for younger patients with aortic insufficiency or stenosis.
- Analysis of outcomes after aortic cusp extension valvuloplasty in infants and children was performed.
Purpose of the Study:
- To evaluate the outcomes of aortic cusp extension valvuloplasty in pediatric patients.
- To assess long-term freedom from aortic valve replacement (AVR) and identify determinants of outcome.
Main Methods:
- Aortic cusp extension valvuloplasty, including pericardial cusp extension and tricuspidization, was performed on 78 patients younger than 10 years between 1987 and 2008.
- Patients included those with bicuspid aortic valve, congenital aortic valve stenosis, or aortic insufficiency/stenosis, with some having prior valvuloplasty.
- Median follow-up was 12.4 years, analyzing freedom from AVR.
Main Results:
- No early or late deaths occurred.
- Actuarial freedom from aortic valve replacement (AVR) at 1, 5, and 10 years was 97.3%, 71.3%, and 55.6%, respectively.
- Left ventricular reverse remodeling was observed post-procedure.
Conclusions:
- Aortic cusp extension valvuloplasty with tricuspidization provides satisfactory long-term durability and freedom from AVR in infants and children.
- This technique is a reliable and effective approach for managing congenital or acquired abnormal aortic valves in pediatric populations.
- The procedure allows for left ventricular reverse remodeling.
Background:
Encouraging early outcomes of emerging aortic cusp extension valvuloplasty techniques have redirected attention to nonreplacement strategies in the management of younger patients with aortic insufficiency or aortic stenosis. Outcome analysis after aortic cusp extension valvuloplasty in infants and children was undertaken.
Methods:
From July 1987 to December 2008, 78 patients younger than 10 years of age underwent aortic cusp extension valvuloplasty in the form of pericardial cusp extension and selective use of tricuspidization. Sixteen (20.5%) patients were younger than 1 year of age. Twenty-seven had bicuspid aortic valve, 34, congenital aortic valve stenosis, and 17, congenital or acquired aortic insufficiency or aortic stenosis. Forty-two patients had balloon valvuloplasty or surgical valvotomy before aortic cusp extension valvuloplasty. Median follow-up was 12.4 years (range, 0.1 to 21.6 years). Freedom from aortic valve replacement (AVR) and determinants of outcome were analyzed.
Results:
There were no early or late deaths. During the follow-up period, 23 patients (29.5%) had Ross operation and 8 patients (10.2%) had other AVR. The z values of left ventricular end-diastolic dimension, aortic annulus, aortic sinus diameter, sinotubular junction diameter, and left ventricular wall thickness before AVR were 3.8 +/- 2.95, 2.1 +/- 1.15, 4.2 +/- 1.22, 1.78 +/- 1.24, and 2.92 +/- 1.31, respectively. Actuarial freedom from AVR at 1, 5, and 10 years was 97.3 +/- 2.0%, 71.3 +/- 5.8%, and 55.6 +/- 6.9%, respectively.
Conclusions:
Aortic cusp extension valvuloplasty with tricuspidization allows left ventricular reverse remodeling with satisfactory long-term durability and freedom from AVR. Used selectively, it represents a reliable and effective approach in infants and children with congenital or acquired abnormal aortic valve.
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