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Updated: Jun 9, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
Spinal neoplasms in small animals
1Neurology and Neurosurgery, Department of Clinical Sciences, Iowa State University, College of Veterinary Medicine, 1600 South 16th street, Ames, IA 50011-1250, USA. rsbagley@iastate.edu
Abstract:
Tumors arising from or involving the spinal cord are important considerations in animals presented for pain and limb dysfunction. Clinical signs of spinal cord dysfunction, however, are not pathognomic for neoplastic disease in most instances. Advanced magnetic resonance imaging (MRI) often accurately identifies the location and extent of abnormalities. Although some spinal neoplasms have a characteristic appearance with MRI, in other instances the abnormalities may not be readily discernable as neoplastic. Histologic diagnosis, therefore, is imperative to provide information regarding potential treatment modalities and prognosis. Histologic diagnosis is most commonly performed following surgical biopsy and is often performed in combination with surgical removal.

