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Interleukin-2 receptor signaling: at the interface between tolerance and immunity

Thomas R Malek1, Iris Castro

  • 1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, PO Box 01960, Miami, FL 33101, USA. tmalek@med.miami.edu

Immunity
|August 25, 2010
PubMed

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo. IL-2R signaling influences two discrete aspects of immune responses by CD8(+) T cells, terminal differentiation of effector cells in primary responses, and aspects of memory recall responses. IL-2 also delivers essential signals for thymic development of regulatory T (Treg) cells and later to promote their homeostasis and function. Each of these outcomes on T effector and Treg cells requires distinct amounts of IL-2R signaling, with low IL-2R signaling sufficient for many key aspects of Treg cells. Thus, tolerance is readily maintained and favored with limited IL-2.

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