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Updated: Jun 9, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Gene-specific epigenetic regulation in serious infections with systemic inflammation
Charles E McCall1, Barbara Yoza, Tiefu Liu
1Translational Science Institute, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. chmccall@wfubmc.edu
Abstract:
Inflammation is a fundamental biologic process that is evolutionally conserved by a germ line code. The interplay between epigenetics and environment directs the code into temporally distinct inflammatory responses, which can be acute or chronic. Here, we discuss the epigenetic processes of innate immune cells during serious infections with systemic inflammation in four stages: homeostasis, incitement, evolution, and resolution. We describe feed-forward loops of serious infections with systemic inflammation that create gene-specific silent facultative heterochromatin and active euchromatin according to gene function, and speculate on the role of epigenetics in survival.
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