Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How do leucocytes perceive chemical gradients?

P C Wilkinson1

  • 1Bacteriology and Immunology Department, University of Glasgow (Western Infirmary), U.K.

FEMS Microbiology Immunology
|December 1, 1990
PubMed
Summary

Chemoattractants guide leucocyte movement direction and speed. New stochastic models explain cell migration in uniform attractant concentrations and gradients, suggesting shared biochemical mechanisms for chemotaxis and chemokinesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cigarette smoking and the antibody response to inhaled antigens.

Immunology today·2014
Same author

Random locomotion; chemotaxis and chemokinesis. A guide to terms defining cell locomotion.

Immunology today·2014
Same author

Assays of leukocyte locomotion and chemotaxis.

Journal of immunological methods·1998
Same author

Antigen-specific chemotaxis of B cells.

Immunology·1997
Same author

TGF-beta stimulates but IFN-gamma inhibits growth-related activation of locomotion of human B cells.

Journal of immunology (Baltimore, Md. : 1950)·1997
Same author

Locomotor properties of human germinal centre B cells: activation by anti-CD40 and IL-4 allows chemoattraction by anti-immunoglobulin.

Immunology·1997

Area of Science:

  • Cellular biology
  • Biophysics
  • Immunology

Background:

  • Chemoattractants influence leucocyte locomotion, affecting both direction (chemotaxis) and speed (chemokinesis).
  • Existing models for gradient detection (spatial, temporal) do not fully explain persistent random migration in uniform attractant fields.
  • The mechanisms linking attractant detection to cell movement persistence and directionality require further elucidation.

Purpose of the Study:

  • To review mechanisms of leucocyte gradient detection.
  • To explore how attractants induce persistent random migration in the absence of gradients.
  • To present stochastic models explaining cell locomotion in both uniform and gradient attractant conditions.

Main Methods:

  • Review of existing spatial and temporal leucocyte gradient detection mechanisms.
  • Development and analysis of stochastic models for cell migration.
  • Theoretical exploration of attractant-induced cell polarization and response to concentration fluctuations.

Main Results:

  • Stochastic models successfully explain persistent random walks in uniform attractant concentrations.
  • These models also account for directional locomotion observed in chemotactic gradients.
  • The findings suggest that the biochemical pathways stimulating chemotaxis and chemokinesis are likely identical.

Conclusions:

  • Stochastic models provide a unified framework for understanding leucocyte migration.
  • Cellular responses to attractants involve polarization and sensitivity to concentration fluctuations.
  • The study posits a shared biochemical basis for chemotaxis and chemokinesis.

Related Experiment Videos