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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Childhood lupus: experience from Eastern India

Rakesh Mondal1, Madhumita Nandi, Suhas Ganguli

  • 1Pediatric Rheumatology Clinic, Department of Pediatrics, Institute of Post graduate Medical Education and Research, Kolkata, India.

Indian Journal of Pediatrics
|August 25, 2010
PubMed

Insights

This study highlights key clinical features of childhood Systemic Lupus Erythematosus (SLE) in Eastern India. Findings reveal distinct disease patterns compared to other global observations, emphasizing the need for regionalized understanding.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Clinical Medicine

Background:

  • Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with varied clinical presentations.
  • Understanding regional differences in pediatric SLE is crucial for effective management.

Purpose of the Study:

  • To characterize the clinical behavior of childhood SLE in Eastern India.
  • To identify unique disease patterns in this specific demographic.

Main Methods:

  • Prospective follow-up of 44 pediatric SLE patients over five years.
  • Analysis of clinical data using standard statistical methods.

Main Results:

  • SLE constituted 3.9% of pediatric rheumatology cases.
  • Renal, hematological, and neuropsychiatric manifestations were most common major organ involvements (54%, 54%, 25%).
  • Female to male ratio was 3.8:1; ANA-negative SLE occurred in two cases presenting with nephritis.

Conclusions:

  • This study delineates specific disease trends of childhood lupus in Eastern India.
  • Observed trends differ from other Indian and international findings, underscoring regional variations.
Abstract

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