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Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies
Published on: November 4, 2021
The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization
Katarzyna Kapczyńska1, Piotr Stefanowicz, Lukasz Jaremko
1Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, Wroclaw, Poland.
Amino Acids
|August 25, 2010
Abstract:
Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes (2)H, (13)C and (18)O.
