Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts Association Tunisienne de Médecine Néonatale (ATMN).

La Tunisie medicale·2026
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Photoproduction of K^{+}K^{-} Pairs in Ultraperipheral Collisions.

Physical review letters·2024
Same author

Emergence of Long-Range Angular Correlations in Low-Multiplicity Proton-Proton Collisions.

Physical review letters·2024
Same journal

[Physiopathology of chronic arthritis following chikungunya infection in man].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Judicial or administrative settlement of medical malpractice claims. Update on medical liability].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Chikungunya epidemic in 2005-2006: questions from occupational health professionals].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Administrative issues linked to health insurance coverage of chronic post-chikungunya rheumatism].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Coverage of the chikungunya epidemic on Reunion Island in 2006 by the French healthcare system].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Five-year outcome of mother-to-child transmission of chikungunya virus].

Medecine tropicale : revue du Corps de sante colonial·2012
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

[Malignant pertussis: an underdiagnosed illness].

A Bouziri1, A Hamdi, A Khaldi

  • 1Service de réanimation pédiatrique, Hôpital d'enfants, Tunis, Tunisie. asma.bouziri@yahoo.fr

Medecine Tropicale : Revue Du Corps De Sante Colonial
|August 26, 2010
PubMed
Summary
This summary is machine-generated.

Malignant pertussis is a severe, often fatal illness in infants, characterized by respiratory failure and high white blood cell counts. Early diagnosis using PCR for Bordetella pertussis is crucial, especially in developing countries.

Related Experiment Videos

Last Updated: Jun 9, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Area of Science:

  • Pediatric Intensive Care
  • Infectious Diseases
  • Neonatology

Background:

  • Malignant pertussis is a rare but life-threatening condition in infants.
  • It presents with severe respiratory failure, extreme leukocytosis, and pulmonary hypertension.
  • Underdiagnosis is a significant challenge in pediatric intensive care units (PICUs).

Purpose of the Study:

  • To determine the prevalence of malignant pertussis in infants admitted to the PICU.
  • To identify infants with severe acute respiratory failure and severe leukocytosis.
  • To assess the diagnostic accuracy of clinical suspicion versus laboratory confirmation.

Main Methods:

  • Retrospective review of medical charts for infants under 3 months old admitted to the PICU (2006-2008).
  • Inclusion criteria: severe acute respiratory failure requiring mechanical ventilation and leukocytosis >50,000/mm3.
  • Polymerase chain reaction (PCR) testing for Bordetella pertussis on stored nasopharyngeal washes (NPW).

Main Results:

  • Ten infants met the criteria; median age was 2.1 months.
  • None of the infants had received pertussis vaccination.
  • PCR confirmed Bordetella pertussis in all ten cases, but only 3 were presumptively diagnosed.
  • Nine out of ten infants died within days of admission due to refractory shock and hypoxemia.

Conclusions:

  • Malignant pertussis is a highly fatal disease with a high mortality rate.
  • The condition was significantly underdiagnosed in the studied PICU.
  • Promoting PCR for Bordetella pertussis detection is recommended, particularly in resource-limited settings.