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Updated: Jun 9, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

[Dengue shock syndrome: decoding the pathophysiology].

S Devignot¹, H Tolou, P Couissinier-Paris

¹Institut de Recherche Biomédicales des Armées, Antenne de Marseille (IMTSSA), Unité de Virologie Tropicale, France.

Medecine Tropicale : Revue Du Corps De Sante Colonial

|August 26, 2010

Summary

This summary is machine-generated.

Dengue shock syndrome is a dangerous complication of dengue fever that is difficult to predict or treat. This review explores its pathophysiology and potential for high-content screening in personalized medicine.

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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

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Published on: November 1, 2018

Area of Science:

Arbovirology
Pathophysiology
Translational Medicine

Context:

Dengue is a significant arbovirosis with severe clinical manifestations.
Dengue shock syndrome (DSS) is a life-threatening complication.
Current management of DSS is challenging due to unpredictable onset and lack of specific treatments.

Purpose:

To review the current understanding of dengue shock syndrome pathophysiology.
To highlight the utility of high-content screening (HCS) methods.
To explore HCS in translational research for understanding individual responses to DSS.

Summary:

Dengue shock syndrome results from complex pathophysiological processes.
Predicting DSS onset and developing targeted therapies remain critical challenges.
High-content screening offers a promising avenue for investigating individual patient responses and advancing therapeutic strategies.

Impact:

Enhances understanding of severe dengue pathophysiology.
Identifies potential for novel diagnostic and therapeutic targets.
Promotes the application of advanced screening technologies in clinical research for arboviral diseases.