Related Experiment Video

Updated: Jun 9, 2026

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

[Tanatogenetic aspects of brain injury associated with hemorrhagic shock in human]

S I Indiaminov

    Sudebno-Meditsinskaia Ekspertiza
    |August 26, 2010
    PubMed

    Cadaverous brains of 21 men and women were available for investigation. All the subjects died in a hospital from hemorrhagic shock (HS) caused by stab injuries to internal organs and blood vessels. In 9 cases, blood and urine contained no traces of ethyl alcohol; it was detected in the blood of 12 cases (1.0-3.8 per thousand). Histological methods were used to examine field 6 of the brain hemispheres, the wall of the third ventricle with a fragment of pituitary, the wall of the fourth ventricle with the adjacent portion of medulla oblongata, and pia mater. It was shown that impossibility of reperfusion of cerebral vessels, especially those involved in microcirculation, plays the leading role in tanatogenesis associated with hemorrhagic shock. "Blockade" of the brain vascular system results in metabolic disturbances in neurons and neuroglia and their lesions regarded as the immediate cause of death. Acute alcohol intoxication concomitant with hemorrhagic shock accelerates tanatogenesis due to serious changes in the brain vascular system, neurons, and neuroglia.

    More Related Videos

    Developing a Clinically Relevant Hemorrhagic Shock Model in Rats08:14

    Developing a Clinically Relevant Hemorrhagic Shock Model in Rats

    Published on: March 22, 2024

    The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects09:00

    The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

    Published on: October 2, 2014

    Related Concept Videos

    Hemorrhagic Stroke ll: Pathophysiology01:29

    Hemorrhagic Stroke ll: Pathophysiology

    A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
    Hemorrhagic Stroke l: Introduction01:17

    Hemorrhagic Stroke l: Introduction

    A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
    Ischemic Stroke ll: Pathophysiology01:15

    Ischemic Stroke ll: Pathophysiology

    An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
    Traumatic Brain Injury l: Introduction01:28

    Traumatic Brain Injury l: Introduction

    DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
    Cerebral Edema ll: Pathophysiology01:22

    Cerebral Edema ll: Pathophysiology

    Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...