[Thyroid morphofunctional changes in acute experimental endotoxicosis in rats]
Related Experiment Video
Updated: Jun 9, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Abstract:
The aim of the study was to investigate morphofunctional changes in the thyroid and its hormonal status of Wistar rats with non-thyroid illnesses caused by acute endotoxicosis. The latter was simulated, by administering the sublethal dose of lipopolysaccharide. Thyroid morphological and morphometric studies on disease days 1 and 7 established that the earliest sign of non-thyroid illnesses was the dissociation of synthetic processes and thyroglobulin release into the lumen of a follicle and its resorption, i.e. desynchronization of the phases of a cell secretory cycle and dissociation of the directionality of morphodynamic processes in the central and peripheral zones of thyroid lobes. Recovery of the unidirectionality of these processes may be interpreted as a sign that suggests the regression of non-thyroid illnesses.
More Related Videos
Related Concept Videos
Graves Disease II: Pathophysiology
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hypothyroidism II: Pathophysiology

