Related Experiment Video
Updated: Jun 9, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Orchitis in lupus/scleroderma overlap syndrome: a case report and literature review
Eman R Boulis1, Vikas Majithia
1Division of Rheumatology, University of Mississippi, Jackson, Mississippi 39216, USA.
Abstract:
Testicular involvement in connective tissue diseases (CTD) is typically caused by medium vessel vasculitis as in polyarteritis nodosa. Systemic lupus erythrematosus (SLE) and systemic sclerosis cause small vessel vasculitis, which is an unusual cause of orchitis. We hereby report a case of orchitis in a 28-year-old patient caused by vasculitis related to his lupus/scleroderma overlap CTD. He had an excellent response to steroids and azathioprine with complete resolution of his testicular and systemic symptoms. Our case highlights that although testicular involvement secondary to small vessel vasculitis in CTD is uncommon, it is still possible and should be evaluated.
Related Concept Videos
Cholecystitis
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Pericarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests
Acute Pyelonephritis II: Diagnostic Studies and Management
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
