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Comparison between substantia innominata and amygdala kindling in rats
N Mori1, S Hoshino, H Kumashiro
1Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Research
|November 26, 1990
Abstract:
Kindling was induced in rats by electrical stimulation of the lateral portion of the substantia innominata (SI). The pattern of seizure development was similar to that of amygdala (AM) kindling. However, lateral SI kindling was associated with ipsilateral head turning as an initial manifestation. In addition, lateral SI kindling had a higher afterdischarge threshold than AM kindling, and the generalized seizure triggering threshold was more unstable in SI kindling than in AM kindling. These findings suggest that lateral SI participates in, but is not essential for, AM seizure development in rats.