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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

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Related Experiment Video

Updated: Jun 9, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

The complexity of HDL.

Gordon A Francis1

  • 1Department of Medicine and UBC James Hogg Research Centre, Providence Heart and Lung Institute, 1081 Burrard St., Vancouver, British Columbia, Canada. gordon.fracis@hli.ubc.ca

Biochimica Et Biophysica Acta
|August 26, 2010
PubMed
Summary

High-density lipoprotein cholesterol (HDL-C) levels don't always predict heart disease risk. Research suggests HDL particle function, not just HDL-C levels, is key to its protective effects.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Biochemistry

Background:

  • Plasma high-density lipoprotein cholesterol (HDL-C) is linked to reduced coronary artery disease (CAD) risk.
  • However, HDL-C levels have exceptions in predicting individual patient outcomes.
  • Emerging evidence points to HDL particle biology beyond HDL-C levels for in vivo effects.

Purpose of the Study:

  • To review the protective role of HDL.
  • To examine current HDL-based therapy evidence in humans and animals.
  • To explore alternatives to HDL-C for assessing HDL function and clinical predictive value.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of animal and human clinical trial data on HDL therapies.

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Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate
11:13

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate

Published on: May 9, 2019

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Last Updated: Jun 9, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate
11:13

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate

Published on: May 9, 2019

  • Examination of HDL particle formation, metabolism, and dysfunction.

    • Main Results:

    • HDL-C levels have limitations in predicting CAD risk.
    • HDL particle function appears more critical than HDL-C levels.
    • Dysfunctional HDL is observed in diabetes and inflammatory conditions.

    Conclusions:

    • HDL's protective effects are complex and not fully captured by HDL-C.
    • Assessing HDL function may offer better clinical prediction than HDL-C alone.
    • Further research into HDL particle biology and function is warranted for therapeutic development.