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Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

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Related Experiment Video

Updated: Jun 9, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

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Published on: July 7, 2016

Intrapericardial triamcinolone administration for autoreactive pericarditis.

Jorie A Glick Frasiolas1, William D Cahoon

  • 1Virginia Commonwealth University Health System, Richmond, USA.

The Annals of Pharmacotherapy
|August 26, 2010
PubMed
Summary

Intrapericardial triamcinolone shows promise for treating autoreactive pericarditis, potentially reducing recurrence. Further research is needed to determine optimal dosing and its exact role in treatment.

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Last Updated: Jun 9, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
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Area of Science:

  • Cardiology
  • Pharmacology
  • Immunology

Background:

  • Systemic corticosteroids are effective for autoreactive pericarditis but have adverse effects and increase recurrence risk.
  • Intrapericardial triamcinolone offers a localized treatment approach for pericarditis.

Purpose of the Study:

  • To review existing literature on the safety and effectiveness of intrapericardial triamcinolone for autoreactive pericarditis.
  • To evaluate the potential of intrapericardial triamcinolone as an alternative to systemic corticosteroids.

Main Methods:

  • Searched MEDLINE and Cochrane Database for English-language articles on human subjects.
  • Included case series, trials, and reports evaluating intrapericardial triamcinolone for autoreactive pericarditis.
  • Evaluated studies for safety and efficacy data, noting limitations in study design and reporting.

Main Results:

  • Limited data from small trials suggest symptom resolution with intrapericardial triamcinolone.
  • Evidence indicates reduced pericarditis recurrence following intrapericardial triamcinolone administration.
  • Studies noted limitations including small sample sizes, lack of control groups, and short follow-up durations.

Conclusions:

  • Growing evidence suggests intrapericardial triamcinolone is safe and effective for managing autoreactive pericarditis.
  • Further investigation is required to establish optimal dosage, treatment duration, and adverse effect profile.
  • The precise therapeutic role of intrapericardial triamcinolone in pericarditis management warrants additional study.