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Bridging the synaptic cleft: lessons from orphan glutamate receptors

Sabine M Schmid1, Michael Hollmann

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA.

Science Signaling
|August 26, 2010
PubMed
Summary

Scientists discovered how synapses are maintained during inactivity. A C1q protein family member, Cbln1, bridges the synaptic cleft by linking postsynaptic GluD2 receptors to presynaptic neurexin, ensuring proper alignment.

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