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Related Experiment Video

Updated: Jun 9, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

B cells and transplantation tolerance.

Allan D Kirk¹, Nicole A Turgeon, Neal N Iwakoshi

¹Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA 30322, USA. adkirk@emory.edu

Nature Reviews. Nephrology

|August 26, 2010

Summary

Achieving transplantation tolerance, a state of immune unresponsiveness without immunosuppressants, is challenging. Recent research highlights B cells

Area of Science:

Immunology
Transplantation Science
Cellular Biology

Background:

Transplantation tolerance, immune unresponsiveness without chronic immunosuppression, is a key goal in organ transplantation.
Renal transplant tolerance is difficult to achieve, and current immunosuppressive drugs have toxic side effects.
B cells play a critical role in both promoting graft rejection and inducing transplantation tolerance.

Purpose of the Study:

To review the mechanisms underlying the induction of B cell-mediated transplantation tolerance.
To survey current and emerging therapies targeting B cells in transplant recipients.

Main Methods:

Literature review of recent studies on B cells in transplantation.
Discussion of immunological mechanisms involved in B cell tolerance induction.

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Survey of therapeutic strategies targeting B cells.

Main Results:

B cells exhibit both antibody-dependent and antibody-independent functions.
These functions contribute to both tolerogenic and rejection-promoting immune responses in transplant recipients.
Understanding B cell roles is crucial for developing new tolerance strategies.

Conclusions:

B cells are pivotal players in the complex immune responses following transplantation.
Targeting B cell functions offers promising avenues for achieving long-term transplantation tolerance.
Further research into B cell mechanisms can guide the development of safer, more effective transplant therapies.