Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Rh Blood Group

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

The ABO Blood Group

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Platelet-Activating Anti-Platelet Factor 4 Disorders.

The New England journal of medicine·2026

Same author

ELISA-negative HIT: antibody recognition and relevance.

Blood·2026

Same author

Experimental Models of Anti-PF4 Immunothrombosis: Mechanistic Insights, Translational Value, and Unmet Needs.

Thrombosis and haemostasis·2026

Same author

Preventing overfilling of blood bags to reduce clot formation and improve donor safety.

Vox sanguinis·2026

Same author

Reducing Bacterial Contamination of Blood Bags with a Double Knot.

The New England journal of medicine·2026

Same author

Platelet-platelet aggregates at single-event resolution as parameter in health monitoring.

Biochemistry and biophysics reports·2026

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Demographic Changes: The Impact for Safe Blood Supply.

Andreas Greinacher¹, Konstanze Fendrich, Wolfgang Hoffmann

¹Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Germany.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie

|August 26, 2010

Summary

European populations are aging, impacting blood supply and demand. Coordinated efforts are needed to prevent future blood shortages due to these demographic shifts.

Related Experiment Videos

Last Updated: Jun 9, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Public Health
Demography
Hematology

Background:

European populations are experiencing significant demographic shifts towards older age groups.
Limited data exists on the impact of these changes on future blood demand and supply.
Current data on blood recipients and donors are sparse and often unconnected.

Purpose of the Study:

To review the effects of demographic change on blood supply and demand in Western societies.
To analyze the impact of demographic trends on blood supply in North America and Europe.
To explore methodological approaches for collecting sociodemographic data on blood donors.

Main Methods:

Literature review of studies on demographic change and blood supply/demand.
Analysis of demographic trends in Western countries, particularly the European Union.
Overview of methodologies for sociodemographic data collection in blood donor populations.

Main Results:

Demographic trends, especially declining birth rates, will similarly affect many Western regions.
The effects are most pronounced in newer European Union member states.
Coordinated strategies are essential to mitigate potential blood shortages.

Conclusions:

Aging populations present a significant challenge to future blood supply.
Proactive, coordinated efforts are necessary to ensure blood availability.
Improved data collection on donor sociodemographics is crucial for future planning.