Related Experiment Video
Updated: Jun 9, 2026

Evaluating Therapeutic and Chemical Toxicity Using Organ-Cultured Porcine Corneas and Epithelial Wound Healing
Published on: January 10, 2025
Over-Treated Corneal Abscess May Be Toxic Keratopathy
P Rubino1, J G Orsoni, A Rampini
1Institute of Ophthalmology, University of Parma, Parma, Italy.
Abstract:
BACKGROUND/AIMS: Keratitis, especially when long-standing and unresponsive to common antimicrobial treatment, leads to a suspicion of fungal aetiology. METHODS: Photographically documented case report. RESULTS: A 65-year-old man with diabetes was referred for corneal abscess unresponsive to antibiotic and antifungal treatment lasting 6 weeks. Corneal biopsy was performed following a 72-hour washout for identification of bacteria and fungi. Previously administered drops were withdrawn and only preservative-free artificial tears were maintained. Neither bacteria nor fungi were cultured. After 2 weeks, the clinical situation had conspicuously improved. CONCLUSION: Over-treatment of corneal affections fearing mycosis may lead to toxic keratopathy.
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