Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 9, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Continuous process for fabrication of size controlled polyimide nanoparticles using microfluidic system.

Takayuki Ishizaka1, Atsushi Ishigaki, Maya Chatterjee

  • 1Research Center for Compact Chemical System, National Institute of Advanced Science and Technology, 4-2-1 Nigatake, Miyagino-ku, Sendai, Miyagi 983-8551, Japan. t-ishizaka@aist.go.jp

Chemical Communications (Cambridge, England)
|August 26, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration.

Blood·2026
Same author

SAMD4 represses VGLL4 mRNA to activate TEAD and promote cancer progression.

Oncogene·2026
Same author

Jean-François Morot-Gaudry (1943-2024): A Life Devoted to Plant Science, Leadership, and Humanity.

Plants (Basel, Switzerland)·2025
Same author

PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis.

Nature communications·2025
Same author

Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation.

NPJ digital medicine·2025
Same author

Adrenal lipoma formation via PI(3,4,5)P<sub>3</sub>/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes.

Proceedings of the National Academy of Sciences of the United States of America·2025

A novel strategy enables continuous polyimide nanoparticle preparation in just 10 seconds. Particle size is precisely controlled by adjusting poly(amic acid) concentration for efficient nanomaterial synthesis.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Polyimide nanoparticles offer unique properties for advanced applications.
  • Efficient and controlled synthesis methods are crucial for nanomaterial development.
  • Short residence time processes are desirable for industrial scalability.

Purpose of the Study:

  • To develop a rapid, continuous method for polyimide nanoparticle synthesis.
  • To demonstrate control over nanoparticle size during continuous production.
  • To utilize microfluidic technology for enhanced synthesis.

Main Methods:

  • A continuous flow system combining a micromixer and a micro heat exchanger was employed.
  • Polyimide nanoparticles were synthesized from poly(amic acid) (PAA).

More Related Videos

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Generation of Size-controlled Poly (ethylene Glycol) Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices
11:08

Generation of Size-controlled Poly (ethylene Glycol) Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Published on: July 3, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Generation of Size-controlled Poly (ethylene Glycol) Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices
11:08

Generation of Size-controlled Poly (ethylene Glycol) Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Published on: July 3, 2018

  • Varying PAA concentration was used as the primary control parameter for particle size.

    • Main Results:

    • Continuous preparation of polyimide nanoparticles was achieved with a short residence time of 10 seconds.
    • Nanoparticle size was found to be proportional to the initial PAA concentration.
    • The system demonstrated efficient and reproducible nanoparticle formation.

    Conclusions:

    • The developed strategy offers a highly efficient method for continuous polyimide nanoparticle production.
    • Precise control over particle size is achievable by simple adjustment of precursor concentration.
    • This approach holds promise for scalable and cost-effective manufacturing of polyimide nanomaterials.