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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular
Adam J M Burrell1, Luke Watson, Nathaniel G Martin
1Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UKS3 7HF.
Abstract:
Condensation of an aldehyde with an α-amino-ester, followed by a tandem process involving cyclization to a seven-membered ring, deprotonation to an intermediate azomethine ylide and intramolecular dipolar cycloaddition gave tricyclic products related to stenine and neostenine.
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