Olfactory bulb transection alters fetal behavior after chemosensory but not tactile stimulation

Rat fetuses respond to an intraoral infusion of lemon extract with an increase in overall activity and facial-wiping behavior. Other studies have suggested a role for olfaction in mediating fetal responses to chemosensory stimuli. In the present study, a micro-knife was used to surgically isolate the main and accessory olfactory bulbs from more caudal structures in the fetal brain. Fetuses that received this transection procedure or a sham treatment showed normal levels of non-evoked motor activity during the period prior to chemosensory infusion. Surgical isolation of the olfactory bulbs had no effect on fetal response to perioral tactile stimulation. Behavioral responses to infusion were diminished but not eliminated in fetuses with olfactory bulb transections. The olfactory bulb, which is functional in spite of its anatomical immaturity, plays a role in the control of fetal behavior.